Shuaiqi Guo
Assistant Professor,听Department of Anatomy and Cell Biology
B.Sc (Mount Allison University), Ph.D. (Queen's University), PDF (Eindhoven University of Technology, Yale University)
Microbial adhesins, biofilms, secretions systems; cryo-electron tomography,
Davies PL, Guo S* (2024) Structures of fibrillar adhesins that mediate bacterium-host interactions and biofilm formations, Springer Biofilm Series
*Corresponding author
Guo S*, Chang Y, Brun YV, Howell PL, Burrows LL*, Liu J* (2024) PilY1 regulates the dynamic architecture of the Type IV Pilus machine in Pseudomonas aeruginosa,听Nature Communications
*Corresponding authors
Lloyd CJ, Guo S, Kinrade B, Zahiri H, Eves R, Khalid Ali S, Yildiz F, Voets IK, Davies PL, Klose KE (2023) A peptide-binding domain shared with an Antarctic bacterium facilitates Vibrio cholerae epithelial cell-binding, biofilm formation and intestinal colonization, Proceedings of the National Academy of Sciences. 120 (39):1-8 PMID:
Guo S, Xu H, Chang Y, Motaleb MdA, Liu J (2022) FliL-ring provides structural basis for maximal torque generation in bacterial flagellar motor, Proceedings of the National Academy of Sciences. Press: Yale School of Medicine
Guo S, Liu J (2022) Rotational switching, torque generation, and mechanosensing: insights into the structures and functions of the bacterial flagellar motor, Frontiers in Microbiology. 3 (9111114): 1-10. PMID:
Guo S, Zahiri H, Stevens CA, Spaanderman DC, Milroy LG, Ottmann C, Brunsveld L, Voets IK, Davies PL (2021) Molecular basis for inhibition of adhesin-mediated bacterial-host interactions through a novel peptide-binding domain, Cell Reports.
Guo S, Vance TDR, Zahiri H, Eves R, Stevens CA, Hehemann JH, Vidal-Melgosa S, Davies PL (2021) Structural basis of ligand selectivity by a bacterial adhesin lectin involved in multi-species biofilm formation, mBio. 12 (2): 1-18. PMID:
Guo S, Dubuc E, Rave Y, Twisk S.A.E., Van der Hek T, Verhagen M.P.A., Oerlemans G.J.M, Van den Oetelaar M.C.M, Van Hazendonk L.S, Sharma M, Br眉ls M, Eijkens B.V, Joostens P.L, Keij S.R, Xing W, Merkx M, Voets K, De Greef T (2020) Engineered living materials based on adhesin-mediated trapping of programmable cells, ACS Synthetic Biology.
Guo S, Vance TDR, Stevens CA, Voets IK, Davies PL (2019) RTX Adhesins are key bacterial surface megaproteins in the formation of biofilms, Trends in Microbiology.
Guo S, Langelaan DN, Phippen SW, Smith SP, Voets IK, Davies PL (2018) Conserved structural features anchor biofilm-associated RTX鈥揳dhesins to the outer membrane of bacteria, The FEBS Journal 10.1111/febs.14441. 285 (10): 1812-1826. PMID:
Guo S, Stevens CA, Vance TDR, Olijve LLC, Graham LA, Campbell RL, Yazdi SR, Escobedo C, Bar-Dolev M, Yashunsky V, Braslavsky I, Langelaan DN, Smith SP, Allingham JS, Voets IK, Davies PL (2017) Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice, Science Advances. Press: , ,
Vance TDR, Olijve LLC, Campbell RL, Voets IK, Davies PL, Guo S * (2014) Ca2+-stabilized adhesin helps an Antarctic bacterium reach out and bind ice. Bioscience Rep. 34 (4): 357-368. PMID:
*Corresponding author
Guo S, Garnham CP, Partha-Karunan S, Campbell RL, Allingham JS, Davies PL (2013) Role of Ca2+ in folding the tandem 尾-sandwich extender domains of a bacterial ice-binding adhesin. The FEBS Journal. 280 (22): 5919-5932. PMID:
Guo S, Garnham CP, Whitney JC, Graham LA, Davies PL (2012) Re-Evaluation of a bacterial antifreeze protein as an adhesin with ice-binding activity. PLoS One. 7 (11): 1-10. PMID: