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UID:20260224T193500EST-3447lUVGei@132.216.98.100
DTSTAMP:20260225T003500Z
DESCRIPTION: \n\nSpeaker:\n\nCharles-Etienne Castonguay\, M. D.\, Ph. D.\n	R
 1 Neurologie\, Institut Neurologique de Montréal\n	Irving Ludmer Psychiatry
  Research and Training Building\n\n \n\nRésumé:\n\nEssential tremor is a m
 ovement disorder characterized by an upper-limb postural and action tremor
 . It is one of the most common neurological disorders\, affecting 1% of th
 e worldwide population. Despite strong evidence for genetic factors drivin
 g the etiology of essential tremor\, the underlying pathophysiology remain
 s poorly understood. To understand the effects of genetic risk factors in 
 essential tremor on the cerebellum\, the brain region suspected to be affe
 cted by the disease\, we built a population-scale single-cell atlas of the
  human cerebellar cortex comprised of over 1 million cells from 109 indivi
 duals. Using single-cell expression quantitative trait loci and Mendelian 
 randomization\, we show that essential tremor-associated variants in the B
 ACE2 locus are causally linked to its downregulation in cerebellar oligode
 ndrocytes. We highlight a genetically vulnerable population of BACE2-expre
 ssing immature oligodendrocytes\, suggestive of demyelination. We also fin
 d dysfunctional processes affecting interactions between neuronal populati
 ons and oligodendrocytes in essential tremor. Our study suggests a crucial
  role for cerebellar oligodendrocytes in the pathogenesis of essential tre
 mor.\n\n \n\nPour participer:\n\nLien Zoom: https://mcgill.zoom.us/j/81367
 247906\n\n \n
DTSTART:20260225T140000Z
DTEND:20260225T150000Z
SUMMARY:Single Cell Club presents: Single-cell expression QTL analyses of t
 he human cerebellum reveal vulnerability of oligodendrocytes in essential 
 tremor
URL:/arts/fr/channels/event/single-cell-club-presents-
 single-cell-expression-qtl-analyses-human-cerebellum-reveal-vulnerability-
 371375
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