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Defining efficient and robust chemical processes to prepare an Active Pharmaceutical Ingredient (API) is foundational to pharmaceutical research. Molecules that are invented to improve the course of human health must be synthesized by routes that don鈥檛 offset those advantages for reasons of excessive waste generation, high manufacturing cost or unreliable supply. The role of the industrial process chemist is, in part, to ensure the positive benefits of these medicines to society as whole are maintained when they are introduced into the marketplace and synthesized time and again over decades of use. In this seminar, process development and the innovations in reaction and process design that underpinned the commercial route for several API鈥檚 will be described.

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Bio:

Don Gauthier received his B.S. in chemistry from the University of Massachusetts, Dartmouth and completed his doctoral thesis at the University of California, Irvine under the guidance of Professor Kenneth J. Shea. After a postdoctoral appointment with Professor Erick Carreira at the California Institute of Technology Don began his industrial career with Merck in 1997. During Don鈥檚 20+ years in Process Research & Development, he has assumed various roles of increasing responsibility. Don鈥檚 early years in Merck Process were spent delivering on pipeline objectives for several early and late phase clinical candidates. During a brief stint in the Merck Labeled Compound Synthesis group, Don pioneered several novel methods to streamline and expedite the production of ¹³C and ¹⁴C labeled clinical candidates. More recently, Don served as a mentor and group leader responsible for designing innovative and efficient manufacturing routes to Merck products, including several late stage clinical candidates and approved products such as Sugammadex ^庐, Ceftolozane^庐 (antibiotic component of Zerbaxa^庐), Gefapixant, Islatravir, Pifeltro^庐 and Delstrigo^庐. Don and his Merck colleagues recently earned consecutive Green Chemistry Challenge awards, first in 2018 for the manufacturing route to Doravirine^庐, and in 2019 for the manufacturing route to Ceftolozane^庐. Don also received the 2021 Edison Patent Award for his work on Doravirine. He is currently a Senior Principal Scientist in the Process Chemistry group in Rahway, NJ.

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