34th Annual James D. Baxter Lectureship
RRD/Baxter Lecture
Speaker: Dr. Anthony Nichols, MD
Professor, Department of Otolaryngology-Head and Neck Surgery and
Department of Oncology, Schulich School of Medicine & Dentistry
Western University
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Title: "Borrowed Science, New Answers: Applying Translational Oncology Methods to Non-Malignant Disease in Head & Neck Surgery鈥�
Objectives:
1.听Describe the molecular and immunological mechanisms听underlying idiopathic subglottic stenosis, including fibroinflammatory pathways implicated in disease recurrence, and evaluate how transcriptomic and single-cell approaches are informing novel treatment strategies beyond serial dilation.
2.听Explain how molecular profiling and cellular biology听have expanded our understanding of laser-induced skin rejuvenation, including the mechanistic basis of fractional CO鈧� and erbium laser effects on dermal remodeling, collagen neosynthesis, and emerging targets for adjunctive pharmacological enhancement.
3.听Analyze the immunological heterogeneity of tonsillar disease听鈥� distinguishing recurrent tonsillitis from obstructive tonsillar hypertrophy at the cellular and transcriptomic level 鈥� and discuss how single-cell RNA sequencing is being applied to identify disease-specific immune signatures with potential diagnostic and therapeutic relevance.
4.听Apply a translational research framework听鈥� traditionally used in oncology 鈥� to benign otolaryngologic and aesthetic conditions, recognizing how rigor in molecular study design, biomarker validation, and evidence hierarchies can elevate the quality of investigation in non-malignant disease.
5.听Understand the important role of the surgeon-scientist听in advancing patient-centred medical research鈥� including identifying concrete institutional, departmental, and funding strategies that academic medical centres can adopt to recruit, protect, and sustain surgeon-scientists
Location: RI-MUHC, ES1.1129