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Black-White disparity in severe cardiovascular maternal morbidity: a systematic review and meta-analysis

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Speak with Xinting Li about her practicum on January 31st from 3:30-4:00pm via this .

Video Presentation

View Xinting Li's poster presentation in this video recording:听

Abstract

翱产箩别肠迟颈惫别听

To summarize existing literature on Black-White disparities in the prevalence of severe maternal cardiovascular morbidity.听

Data Sources

We systematically searched MEDLINE, EMBASE, and CINAHL for studies published before July 31, 2021 that compared the risk of severe maternal cardiovascular morbidity between Black and White women.听

Study Eligibility Criteria听

We included observational cohort, case-control, and cross-sectional studies comparing outcomes between pregnant Black and White patients. The outcome was severe maternal cardiovascular morbidity, including acute myocardial infarction, peripartum cardiomyopathy, and stroke during pregnancy, delivery, or postpartum.听

Study Appraisal And Synthesis Methods听

We extracted relevant information including adjusted and unadjusted effect estimates, and assessed the quality of studies using the Newcastle-Ottawa scale. We used random-effects models to estimate the pooled association between race and severe maternal cardiovascular morbidity, and present results as odds ratios with 95% confidence intervals for the comparison of Black relative to White women.听

Results听

We included 18 studies that met the eligibility criteria for systematic review and meta-analysis. All studies were conducted in the U.S. and included a total of 7,656,876 Black women and 26,412,600 White women. Risk of bias was low for most included studies. Compared with White women, Black women had an increased risk of any severe maternal cardiovascular morbidity (adjusted odds ratio, 1.90; 95% confidence interval, 1.54-2.33). Black women were at risk of acute myocardial infarction (adjusted odds ratio, 1.38; 95% confidence interval, 1.14-1.68), peripartum cardiomyopathy (adjusted odds ratio, 1.71; 95% confidence interval, 1.51-1.94), and stroke (adjusted odds ratio, 2.13; 95% confidence interval, 1.39-3.26).听

Conclusion听

Black women have a considerably higher risk of severe maternal cardiovascular morbidity than White women, including acute myocardial infarction, peripartum cardiomyopathy, and stroke. Reducing inequality in adverse cardiovascular outcomes of pregnancy between Black and White women should be a priority.听

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