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Event

Omega-3 Supplementation in Preterm Neonates The DHA Dilemma: Why Trials Disagree, How the Evidence Has Evolved, and Where It Is Heading

Monday, February 23, 2026 15:30to16:30

JOINT CORE/EBOH EPI Seminar Series Winter 2026

The Seminars in Epidemiology organized by the Department of Epidemiology, Biostatistics and Occupational Health at the 成人VR视频 School of Population and Global Health is a self-approved Group Learning Activity (Section 1) as defined by the maintenance of certification program of the Royal College of Physicians and Surgeons of Canada. Physicians requiring accreditation, please complete the Evaluation Form and send to admincoord.eboh [at] mcgill.ca.

Mireille Guillot, MD, MSc, FRCPC

Assistant Professor, Department of Pediatrics
Faculty of Medicine - Universit茅 Laval

WHEN: Monday, FEBRUARY 23, 2026, from 3:30-4:30pm
WHERE: Hybrid | 2001 成人VR视频 College, Rm 1140 &
5252 boul. de Maisonneuve - 3rd floor, Kitchen &
Note: Mireille Guillot will be presenting from Universit茅 Laval

Abstract

Very preterm neonates miss the critical third-trimester placental transfer of omega-3 docosahexaenoic acid (DHA), prompting widespread interest in postnatal supplementation. DHA plays a critical role in retinal and cerebral development and may help modulate inflammation and oxidative stress. Despite this strong biological rationale, randomized trials of DHA supplementation in this population have produced inconsistent results, leading to uncertainty regarding clinical benefits and risks. This presentation reviews the evolving evidence on omega-3 supplementation in very preterm neonates, focusing on key sources of heterogeneity across trials, including dose, timing, outcome definitions, and the balance between DHA and arachidonic acid. Drawing on two decades of research and recent advances in evidence synthesis, the presentation highlights implications for major neonatal and neurodevelopmental outcomes and outlines remaining knowledge gaps and priorities for future studies aimed at informing clinical decision-making.

Learning Objectives

At the completion of this talk, attendees will be able to:

  • Understand the biological rationale for omega-3 (docosahexaenoic acid, DHA) supplementation in neonates born very preterm;
  • Review the current evidence from randomized trials and meta-analyses evaluating omega-3 DHA supplementation in very preterm infants, including potential benefits and risks;
  • Identify key knowledge gaps and research priorities in omega-3 supplementation strategies for preterm neonates.

Speaker Bio

Dr Mireille Guillot is an Assistant Professor in the Department of Pediatrics, a neonatologist, and a clinician-scientist at the CHU de Qu茅bec鈥揢niversit茅 Laval. After completing her pediatric residency and neonatology fellowship training, she completed a research-intensive fellowship in Neonatal Neurology at The Hospital for Sick Children, University of Toronto. In parallel, she completed a Master鈥檚 in Epidemiology at University of Toronto.

Her research focuses on identifying modifiable risk factors in the neonatal period, including neonatal nutrition, to improve brain development and long-term outcomes in children born preterm. As an early-career investigator and FRQS Junior 1 research award recipient, she is building a rapidly expanding research program in close collaboration with experts in perinatology, neurodevelopment, hemodynamics, and nutrition.

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