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Dr. Koromilas聽lab investigates the translational and signaling properties of the phosphorylation of the 伪 subunit the translation initiation factor eIF2 at serine 51 (eIF2伪S51P) in stress responses associated with tumor formation and treatment with chemotherapeutic drugs. We also investigate the cell-autonomous function of the transcription factor Stat1 in the inhibition of oncogenic pathways in tumor cells and regulation of tumor responses to treatments with anti-tumor drugs. We employ human and mouse models of solid (breast, lung, colon) and hematopoietic cancers (CML) to better understand the function of eIF2伪S51P and Stat1 in cancer in the hope of developing better therapies to combat cancer.