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For many years, my research has focused on two main research areas: mass spectrometry-based quantitative proteomics and structural proteomics. Quantitative proteomics has innumerable medical applications (e.g., diagnostics for diseases including cancer and heart disease), and includes biomarker discovery and quantitation, and translation of accurate quantitative assays into the clinic. Structural proteomics includes the study of protein folding and misfolding, which is thought to play a role in diseases such as Parkinson's disease, Huntington's disease, Creutzfeldt-Jakob disease, cystic fibrosis, and type-2 diabetes. The proteins involved in these diseases are therefore potential targets for drugs that could prevent or even reverse this misfolding.