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Dr. Javier Di Noia

Academic title(s): 

Full Professor - Institut de Recherches Cliniques de Montr茅al (IRCM)
Professor 鈥� Department of Medicine, University of Montreal
Adjunct Professor 鈥� Department of Medicine, 成人VR视频
Adjunct Professor 鈥� Department of Microbiology and Immunology, 成人VR视频

Dr. Javier Di Noia
Contact Information
Address: 

Institut de Recherches Cliniques de Montr茅al (IRCM)
110 Pine Avenue,
Montreal, Qc, H2W 1R7

Phone: 
(514) 987-5642
Email address: 
javier.dinoia [at] mcgill.ca
Alternate email address: 
javier.marcelo.di.noia [at] ircm.qc.ca
Link(s): 
Website (成人VR视频)
Current research: 

Our laboratory studies B lymphocytes by using molecular, biochemical and immunological assays, tissue culture of cell lines and primary B cells, as well as genetically modified mouse models, to investigate:

1.Molecular mechanism of antibody diversification.聽We are interested in identifying those mechanisms that regulate the programmed mutagenic processes that change the antibody affinity and isotype after B cells are activated by cognate antigen. We focus on the regulation of the mutagenic enzyme Activation induced deaminase (AID), which when defective underpins immunodeficiency and when deregulated is oncogenic. We also study the interplay of AID with DNA repair mechanisms.
2.Mechanisms promoting survival of B cells within the germinal center.聽The germinal center is a harsh microenvironment where B cells proliferate while undergoing programmed DNA damage. We are interested in key enzymes that permit the B cells to survive this particularly harsh microenvironment, and therefore mount an efficient antibody-mediated immune response.

Projects: 

1.聽 Regulation of antibody gene diversification by active mutagenesis.
2.聽 Oncogenic side effects of antibody gene diversification during immune responses.
3.聽 Germinal center B cell dynamics for an optimal antibody response.
4.聽 Regulation of enzymatic deoxycytidine deamination.

Selected publications: 
  1. Methot SP, Litzler LC, Subramani GP, Eranki A, Fifield H, Patenaude A-M, Gilmore JC, Santiago GE, Bagci H, C么t茅 J-F, Larijani M, Verdun RE, Di Noia JM. A licensing step links AID to transcription elongation for B cell mutagenesis. Nature Communications, 2018, 9(1):1248. doi: 10.1038/s41467-018-03387-6.
  2. Cortizas E, Zahn A, Shiva S, Reed JA, Vega F, Di Noia JM, Verdun RE. UNG protects B cells from AID-induced telomere loss. J. Exp. Med. 2016, 213(11), 2459-2472.
  3. Methot SP and Di Noia JM. Pharmacological manipulation of AID. Oncortarget 2015; 6:26550-26551.

Research areas: 
Immunology
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