From left to right: Jessica Perez, Seema Ambereen, Daniel Cooper, Simon Valli猫res, Sangkyu Lee, Andr茅 Diamant, Norma Ybarra and听Asha Jeyaseelan
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At the radiobiology laboratory, the general research interests are in the areas of oncology bioinformatics, multimodality image analysis, and treatment outcome modeling. The primary motivation is to design and develop novel approaches to unravel the response of cancer patients to chemo-radiotherapy treatment by integrating physical, biological, and imaging information into advanced mathematical models. These models could be used to personalize the chemo-radiotherapy treatment of cancer patients based on predicted benefit/risk. We also investigate the use of bone marrow derived stem cells in the reduction of radiation pneumonitis, one of the most common side effects observed in lung cancer patients after irradiation. For this, we developed an animal (rat) model of radiation pneumonitis, and tested different administration routes of Mesenchymal stem cells derived from bone marrow. We are also interested in investigation alternative therapies that potentially will reduce radiotherapy side effects.
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Recent publications
- Maria, O. M., Maria, A. M., Ybarra, N., Jeyaseelan, K.,听Lee, S.,听Perez, J., ... &听El Naqa, I.听(2015).听Mesenchymal Stem Cells Adopt Lung Cell Phenotype in Normal and Radiation-induced Lung Injury Conditions. Applied immunohistochemistry & molecular morphology: AIMM/official publication of the Society for Applied Immunohistochemistry.
- Vallieres, M.,听Boustead, A., Laberge, S., Levesque, I. R., &听El Naqa, I.听(2015).听SU-EJ-250: A Machine Learning Approach for Creating Texture-Preserved MRI Tumor Models From Clinical Sequences. Medical physics, 42(6), 3323-3324.
- Valli猫res, M., Freeman, C. R., Skamene, S. R., &听El Naqa, I.听(2015).听A radiomics model from joint FDG-PET and MRI texture features for the prediction of lung metastases in soft-tissue sarcomas of the extremities.听Physics in medicine and biology, 60(14), 5471.
- Lee, S., Ybarra, N., Jeyaseelan, K.,听Seuntjens, J.,听El Naqa, I., Faria, S., ... & Robinson, C. (2015).听Bayesian network ensemble as a multivariate strategy to predict radiation pneumonitis risk. Medical physics, 42(5), 2421-2430.
- Coates, J., Jeyaseelan, A. K., Ybarra, N., David, M., Faria, S., Souhami, L., ... &听El Naqa, I. (2015).听Contrasting analytical and data-driven frameworks for radiogenomic modeling of normal tissue toxicities in prostate cancer. Radiotherapy and Oncology.
- Hatt, M., Majdoub, M.,听Vallieres, M., Tixier, F., Le Rest, C. C., Groheux, D., ... & Visvikis, D. (2015).听18F-FDG PET Uptake Characterization Through Texture Analysis: Investigating the Complementary Nature of Heterogeneity and Functional Tumor Volume in a Multi鈥揅ancer Site Patient Cohort. Journal of Nuclear Medicine, 56(1), 38-44.
- Lee, S., Stroian, G., Kopek, N., AlBahhar, M.,听Seuntjens, J., &听El Naqa, I.听(2012).听Analytical modelling of regional radiotherapy dose response of lung. Physics in medicine and biology, 57(11), 3309.
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