Timothy E Kennedy, PhD
Le laboratoire de Timothy Kennedy s鈥檌nt茅resse aux m茅canismes mol茅culaires qui guident le neurod茅veloppement et 脿 leur action sur l鈥檕rganisation et la plasticit茅 du syst猫me nerveux central de mammif猫res adultes. Ces 茅tudes visent 脿 d茅terminer les signaux biochimiques qui commandent le mouvement des cellules et des axones, ainsi que les signaux 茅mis par les cibles 脿 atteindre qui leur indiquent d鈥檃rr锚ter une fois rendus et de faire les connexions appropri茅es avec les cellules voisines.
Des membres du laboratoire 茅tudient les m茅canismes cellulaires et mol茅culaires qui dirigent le guidage axonal, la migration des pr茅curseurs oligodendrocytaires, la my茅linisation, la formation synaptique et la plasticit茅 synaptique.
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Lai Wing Sun K, Correia JP, Kennedy TE (2011) Netrins: versatile extracellular cues with diverse functions. Development, 138(11):2153-69.
Xu B, Goldman JS, Rymar VV, Forget C, Lo PS, Bull SJ, Vereker E, Barker PA, Trudeau LE, Sadikot AF, Kennedy TE. (2010) Critical Roles for the Netrin Receptor DCC in Dopaminergic Neuronal Precursor Migration, Axon Guidance, and Axon Arborization. Neuroscience. 169(2):932-49.
Rajasekharan S, Baker KA, Horn KE, Jarjour AA, Antel JP, Kennedy TE (2009) Netrin-1 and DCC Regulate Oligodendrocyte Process Branching and Membrane Extension via Fyn and RhoA. Development, 136:415-426.
B茅lisle JM, Correia JP, Wiseman PW, Kennedy TE, Santiago Costantino (2008) Patterning protein concentration using laser-assisted adsorption by photobleaching, LAPAP. Lab on a Chip. 8(12): 2164-2167.
Jarjour AA, Bull SJ, Almasieh M, Rajasekharan S, Baker KA, Mui J, Antel JP, Di Polo A, Kennedy TE (2008) Maintenance of Axo-Oligodendroglial Paranodal Junctions Requires DCC and Netrin-1. Journal of Neuroscience. 28: 11003-11014.
Moore SW, Correia J, Lai Wing Sun K, Pool M, Fournier AE, and Kennedy TE. (2008) Rho Inhibition Recruits DCC to the Neuronal Plasma Membrane and Enhances Axon Chemoattraction to Netrin-1, Development, 135(17):2855-64.
Baker KA, Moore SW, Jarjour AA, and Kennedy TE (2006) When a diffusible axon guidance cue stops diffusing: Roles for netrins regulating adhesion and morphogenesis. Current Opinion in Neurobiology 16(5):529-534.
Shekarabi M, Moore SW, Tritsch NX, Morris SJ, Bouchard JF, Kennedy TE (2005). DCC binding netrin-1 mediates cell-substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. Journal of Neuroscience. 25: 3132-3141.
