Jack P Antel, MD
Professor
Associate Member,聽Department of Microbiology &聽Immunology
Dr. Jack Antel鈥檚 research program focuses on using human neural and immune cells to understand how their interactions contribute to the development of neurological disease, specifically multiple sclerosis. His studies include how immune cells reach the central nervous system, how the state of activity of the endogenous glial cells contributes to persistence of the immune response, and how the immune mediators induce injury of the target cells, namely oligodendrocytes and neurons and their processes. These studies also aim to understand how the nervous system is able to repair itself from such injury.
Neuroimmunological Diseases
Healy LM, Jang JH, Won SY, Lin YH, Touil H, Aljarallah S, Bar-Or A,聽Antel聽JP,聽MerTK-mediated regulation of myelin phagocytosis by macrophages generated from patients with MS. Neurol Neuroimmunol Neuroinflamm November 2017 vol. 4 no. 6 e402
Albert M, Barrantes-Freer A, Lohrberg M,聽Antel聽JP, Prineas JW, Palkovits M, Wolff JR, Br眉ck W, Stadelmann C.Synaptic pathology in the cerebellar dentate nucleus in chronic multiple sclerosis. Brain Pathol. 2017 Nov;27(6):737-747
Rao VTS, Khan D, Cui QL, Fuh SC, Hossain S, Almazan G, Multhaup G, Healy LM, Kennedy TE,聽Antel聽JP. Distinct age and differentiation-state dependent metabolic profiles of oligodendrocytes under optimal and stress conditions. PLoS One. 2017 Aug 8;12(8).
Owen DR, Narayan N, Wells L, Healy L, Smyth E, Rabiner EA, Galloway D, Williams JB, Lehr J, Mandhair H, Peferoen LA, Taylor PC, Amor S,聽Antel聽JP, Matthews PM, Moore CS. Pro-inflammatory activation of primary microglia and macrophages increases 18鈥塳Da translocator protein expression in rodents but not humans. J Cereb Blood Flow Metab. 2017 Aug;37(8):2679-2690.
Ghadiri M, Fitz-Gerald L, Rezk A, Li R, Nyirenda M, Haegert D, Giacomini PS, Bar-Or A,聽Antel聽J. Reconstitution of the peripheral immune repertoire following withdrawal of fingolimod. Mult Scler. 2017 Aug;23(9):1225-1232.
Haenseler W, Sansom SN, Buchrieser J, Newey SE, Moore CS, Nicholls FJ, Chintawar S, Schnell C,聽AntelJP, Allen ND, Cader MZ, Wade-Martins R, James WS, Cowley SA. A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response. Stem Cell Reports. Jun 6;8(6):1727-1742.
Levtova N, Healy LM, Gonczi CMC, Stopnicki B, Blain M, Kennedy TE, Moore CS,聽Antel聽JP, Darlington PJ. Comparative morphology and phagocytic capacity of primary human adult microglia with time-lapse imaging. J Neuroimmunol. 2017 Sept 15; 310:143-149.
Cui QL, Khan D, Rone M, Rao V, Johnson RM, Lin YH, Bilodeau PA, Hall JA, Rodriguez M, Kennedy TE, Ludwin SK,聽Antel聽JP Sublethal oligodendrocyte injury: A reversible condition in multiple sclerosis? Ann Neurol. 2017 Jun;81(6):811-824.
Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, Gylys KH, Cahalan MD, Cummings BJ,聽Antel聽JP, Mortazavi A, Carson MJ, Poon WW, Blurton-Jones M. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron 2017 Apr 19;94(2):278-293.
Owens R, Grabert K, Davies C, Alfieri A,聽Antel聽J, Healy L, Mccoll B. Divergent neuroinflammatory regulation of microglial TREM expression and involvement of NF-kappaB.聽Frontiers in Cellular Neuroscience - 2017 Mar 2;11:56.
Ehrlich E, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann AL, Cui QL, Kim K, Bachelin C, Marteyn A, Johnson RM,聽Antel聽J, Sterneckert J, Zaehres H, Schoeler H, Baron-Van Evercooren A,and 聽Kuhlmann T. Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors Proc Natl Acad Sci 鈥� 2017 Mar 14;114(11):E2243-E2252.