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We develop cutting-edge computational approaches to key questions in genomics and evolution. We design algorithmic, machine learning, and statistical approaches to solve real-world questions from biology, and work in tight collaboration with biologists, biochemists, and geneticists to put our tools to use to make biological discoveries. We are particularly interested in: (i) How do genomes evolve, and what does that tell us about their functions? (ii) How is gene expression regulated, and what role does 3D chromosome organization play?