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Sirui Zhou

Academic title(s): 

Assistant Professor,听Department of Human Genetics

Member, Canada Excellence Research Chair in Genomic Medicine

Investigator, Victor Phillip Dahdaleh Institute of Genomic Medicine

Sirui Zhou
Contact Information
Address: 

740 Dr Penfield Ave, Room 7101
Montr茅al, Qu茅bec, Canada, H3A 0G4

Email address: 
sirui.zhou [at] mcgill.ca
Phone: 
(514) 398-8364
Department: 
Human Genetics
Area(s): 
Genetics
Infectious Diseases
Degree(s): 

PhD, Universit茅 de Montr茅al, 2017. Under the supervision of Dr. Guy Rouleau, the Neuro.

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Biography: 

Sirui听Zhou joined the Department of Human Genetics and the Canada Excellence Research Chair in Genomic Medicine as an assistant professor in January 2022. She obtained her PhD from the Universit茅 de Montr茅al in 2017, under the supervision of Dr. Guy Rouleau at the Neuro. Her PhD trainings were focused on the genetic architecture of Nunavik Inuit and intracranial aneurysms in founder populations of Quebec. Later, she pursued her studies in the lab of Dr. Brent Richards at the LDI, as a CIHR postdoctoral fellow. She leveraged multi-omics data and used genetic epidemiological methods to identify tractable biomarkers for osteoporosis, and during the pandemic, to identify potential drug targets for severe COVID-19.

Current research: 

Blood proteins can reflect the biological processes in tissues and thus are the first indicators of disease. They could be directly targeted for therapeutic intervention if the causal relationship between proteins and diseases are elucidated. Environmental and genetic factors associated with different ancestries may also reflect the change in proteomics and interactions between different omics, which could be leveraged to identify targets for disease. Currently, I am interested in using the proteomic, metabolomic and genomic data from the BQC19 (Banque qu茅b茅coise de la COVID-19) and other large biobanks to explore potential targets that contribute to the risks to severe SARS-CoV2 infection and other related traits in multiple populations

Link(s): 
Selected publications: 
  • Butler-Laporte, G, Gonzalez-Kozlova, E, Su, CY, Zhou, S, Nakanishi, T, Brunet-Ratnasingham, E听et al.. Correction: The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals. Clin Proteomics. 2022;19 (1):40. doi:听. PubMed听听PubMed Central听.
  • Lu, T, Forgetta, V, Greenwood, CMT, Zhou, S, Richards, JB. Circulating Proteins Influencing Psychiatric Disease: A Mendelian Randomization Study. Biol Psychiatry. 2023;93 (1):82-91. doi:听. PubMed听听.
  • Sun, X, Xiao, W, Li, Z, Zhou, S, Dong, M, Huang, C听et al.. Does vitamin D supplementation improve bone health, body composition and physical performance beyond endurance exercise in patients with type 2 diabetes: A secondary analysis of randomized controlled trial. Front Physiol. 2022;13 :1003572. doi:听. PubMed听听PubMed Central听.
  • Butler-Laporte, G, Gonzalez-Kozlova, E, Su, CY, Zhou, S, Nakanishi, T, Brunet-Ratnasingham, E听et al.. The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals. Clin Proteomics. 2022;19 (1):34. doi:听. PubMed听听PubMed Central听.
  • Paranjpe, I, Jayaraman, P, Su, CY, Zhou, S, Chen, S, Thompson, R听et al.. Proteomic Characterization of Acute Kidney Injury in Patients Hospitalized with SARS-CoV2 Infection. medRxiv. 2022; :. doi:听. PubMed听听PubMed Central听.
  • Smith-Byrne, K, Cerani, A, Guida, F, Zhou, S, Agudo, A, Aleksandrova, K听et al.. Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements. Cancer Epidemiol Biomarkers Prev. 2022;31 (10):1966-1974. doi:听. PubMed听听PubMed Central听.
  • Duncan, CJA, Skouboe, MK, Howarth, S, Hollensen, AK, Chen, R, B酶rresen, ML听et al.. Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic. J Exp Med. 2022;219 (6):. doi:听. PubMed听听PubMed Central听.
  • Brunet-Ratnasingham, E, Anand, SP, Gantner, P, Dyachenko, A, Moquin-Beaudry, G, Brassard, N听et al.. Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality. Sci Adv. 2021;7 (48):eabj5629. doi:听. PubMed听听PubMed Central听.
  • Chen, Y, Forgetta, V, Richards, JB, Zhou, S. Health Effects of Calcium: Evidence From Mendelian Randomization Studies. JBMR Plus. 2021;5 (11):e10542. doi:听. PubMed听听PubMed Central听.
  • Nilsson, KH, Henning, P, El Shahawy, M, Nethander, M, Andersen, TL, Ejersted, C听et al.. RSPO3 is important for trabecular bone and fracture risk in mice and humans. Nat Commun. 2021;12 (1):4923. doi:听. PubMed听听PubMed Central听.
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