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Overview

BIEN : Fundamental and quantitative overview of RNA biologics. Introduction to RNA biologics associated biomanufacturing unit operations in upstream (design tools and large-scale production systems of DNA templates for in vitro RNA transcription; small-scale and large-scale RNA bioprocessing systems), and downstream approaches for RNA purification (like Tangential flow filtration and RNA-specific chromatography systems) for emerging mRNA therapeutics. Introduction to established and emerging applications of RNA biologics for gene and cell therapy.

Terms: Winter 2025

Instructors: Sudalaiyadum Perumal, Ayyappasamy (Winter)

• Prerequisites: BIEN 590 or permission of the instructor

• Corequisites: BIEN 670

• The course includes guest lectures from academic and industry experts in the field of RNA as therapeutics for synthesis, purification, formulation and scale-up of RNA biologics.