INTRODUCTION: The gut microbiome influences cardiovascular health through metabolite production and immune modulation. Gut microbial dynamics and cardiovascular outcomes are also shaped by biological sex. However, sex-specific responses to myocardial infarction (MI) that involve the gut microbiome and intestinal milieu remain poorly defined, particularly in older hosts. Here, we characterize gut microbiome structure and function alongside physiological and immune responses to MI across multiple...
No abstract
CONCLUSIONS: The survey identified potential weaknesses in novel pathogen preparedness with respect to diagnostic capacity for OROV testing at specialized travel medicine clinics participating in two international networks. These findings provide an opportunity to implement measures to improve communication and planning and to strengthen diagnostic infrastructure prior to future outbreaks.
No abstract
CONCLUSIONS: Subinhibitory exposure to antibiotics without intrinsic antipseudomonal activity reproducibly selected for heritable multidrug-resistant phenotypes in P. aeruginosa. Convergent mutations arose in regulatory genes classically associated with direct antipseudomonal antibiotic pressure, demonstrating that resistance architectures can be selected independent of target engagement and underscoring the potential for collateral resistance under antibiotic stress.
BACKGROUND: Hepatitis C virus (HCV) and skin and soft tissue infections (SSTIs) are common among people who inject drugs (PWID) and represent a considerable burden for individuals and healthcare systems. Engagement in HCV treatment may have positive spillover effects, reducing rates of other health outcomes and healthcare utilization. We aimed to examine such effects among PWID living with HCV.
CONCLUSIONS: Post-arboviral symptoms and impaired QOL persisted beyond six months after chikungunya, dengue and Zika. In contrast, post-malaria fatigue syndrome resolved within three months.
During September 2025-January 2026, 111 travellers (61 female/50 male; median age: 53 years) who acquired chikungunya virus (CHIKV) in Cuba were reported to GeoSentinel. Upon return, 64.2% (70/109) were potentially viraemic. Only 8.2% (9/98) had received pre-travel consultations. The CHIKV was of East-Central-South Africa genotype, closely related to Brazilian strains. International travellers can serve as arboviral outbreak sentinels and, if viraemic, risk introducing CHIKV into areas with...
CONCLUSIONS: HIVST uptake has increased in Africa, with wide variation between countries. HIVST is more likely to engage 25-34-year-olds and men, who have historically been less likely to be aware of their HIV status. Our results can help understand patterns of use and support countries in optimizing their HIV testing services.
Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the development of novel therapeutics. However, for decades, very few laboratories had access to this critical resource and experiments on human islets were typically underpowered. More recently, multiple consortia around the world have started to enable islet biology at scale, enriching our understanding...
Helminth infections in grazing ruminants are of major concern for animal welfare and cause substantial economic losses, prompting the widespread use of ivermectin (IVM). The emergence of IVM resistance, driven by complex and poorly understood mechanisms, increasingly compromises treatment efficacy. Drug efflux transporters, particularly P-glycoproteins (PGPs), are suspected to contribute to resistance. Yet, the study of their individual and functional role is hindered by their diversity in...
Several issues that affect prevention and treatment of heartworm infections require more intensive research. The incidence of heartworm infection in the USA is increasing, but the factors that underlie this trend remain incompletely understood. The contributions of climate change, vector range expansion, client compliance and resistance to macrocyclic lactones (ML) are likely interrelated and require investigation. Molecular-level research has not yet identified the causative mechanisms...
Independent protein-protein interaction networks in kinetoplastid parasites show little overlap, often interpreted as biological divergence. We argue that this pattern largely reflects fragmented sampling. Integrating interactomes from Trypanosoma brucei, Trypanosoma cruzi, and Leishmania donovani improves functional coverage and interpretability while preserving lineage-specific assemblies, providing a framework for hypothesis generation across species.
No abstract
