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Cristian O'Flaherty

Academic title(s): 

Professor, Dep. Surgery (Urology), ³ÉÈËVRÊÓƵ
Associate member, Dep. Pharmacology and Therapeutics, ³ÉÈËVRÊÓƵ
Associate member, Dep. Anatomy and Cell Biology, ³ÉÈËVRÊÓƵ
Associate member, Dep. Medicine (Experimental Medicine Division)

Co-Director of the ³ÉÈËVRÊÓƵ Centre for Research in Reproduction and Development (2018-2021)

Cristian O'Flaherty
Contact Information
Email address: 
cristian.oflaherty [at] mcgill.ca
Phone: 
(514) 934-1934, ext.: 35410
Location: 
Research Institute of the ³ÉÈËVRÊÓƵ Centre, Glen site
Division: 
Urology
Degree(s): 

D.V.M.; Ph.D.

Awards, honours, and fellowships: 

2019: Asian Journal of Andrology Outstanding Paper Award (Notice of award: July 2020).
2017: Molson Foundation Award, ³ÉÈËVRÊÓƵ Health Centre Foundation.
2017: Asian Journal of Andrology Outstanding Paper Award.
2016-2018 : Fonds de Recherche du Québec-Santé (FRQS) Chercheur Boursier Junior 2.
2011: Research Scholar of the Club de Recherches Cliniques du Québec.
2010-2014: FRQS Chercheur Boursier Junior 1.
2010: CIHR-IHDCYH New Investigator Travel award. Vancouver, BC.
2010: International Society of Andrology best oral presentation, Fifth International Conference in Epididymis, Sao Paulo, Brazil.
2008-2011: The Klaassen – Hawthorne Memorial Fellowship, Research Institute, ³ÉÈËVRÊÓƵ Health Centre.

Current research: 

CIHR

Clinical Interests: 

Male infertility

Research interests:

• Redox signaling in spermatogenesis, epididymal maturation and sperm activation
• Regulation of apoptosis in the testis
• Phosphorylation events involved in sperm activation
• Male infertility
• Toxicology of male reproduction

Language(s) spoken: 
English
French
Spanish
Biography: 

Dr. Cristian O’Flaherty is a professor in the Department of Surgery (Division of Urology) at ³ÉÈËVRÊÓƵ and a medical scientist at the Research Institute of the ³ÉÈËVRÊÓƵ Health Centre. He is also an associate member of the Departments of Pharmacology and Therapeutics, Anatomy and Cell Biology, and Experimental Medicine, ³ÉÈËVRÊÓƵ. Dr. O’Flaherty was Co-Director of the ³ÉÈËVRÊÓƵ Centre for Research in Reproduction and Development during 2018-2021. He is an associate editor of Andrology, Human Reproduction, and Antioxidants Journal and a member of the Editorial Board of the Biology of Reproduction.

With a background in the biology of reproduction, he holds a D.V.M and Ph.D. in animal physiology and biochemistry degrees from the University of Buenos Aires, Argentina. He completed his postdoctoral studies in sperm physiology and toxicology at the Urology Division and the Department of Pharmacology and Therapeutics at ³ÉÈËVRÊÓƵ. He was awarded the Chercheur-boursier (Junior 2) award from the Fonds de la Recherche en Santé du Québec (FRSQ), and his research program has been and is currently funded by different agencies including the Canadian Institutes of Health Research, FRQS and the Fonds de Recherche Nature et technologies. His research program focuses on male reproduction particularly on the molecular mechanisms involved in the production and function of healthy spermatozoa, sperm activation and the role of reactive oxygen species in sperm physiology and toxicology. His current work includes the use of mouse models and clinical studies in infertile men to elucidate the role of the antioxidant enzymes called peroxiredoxins in the regulation of sperm function using genomic, proteomic and biochemical approaches. Moreover, Dr. O’Flaherty’s laboratory is working on the molecular mechanism that regulates sperm activation and developing novel diagnostic and therapeutic tools for infertile men.

Selected publications: 

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