Stefano Stifani, PhD
Les objectifs des travaux effectu茅s au laboratoire du Pr听Stefano Stifani sont les suivants.
- Comprendre les m茅canismes mol茅culaires qui r茅gulent l鈥檃utorenouvellement, la prolif茅ration et la diff茅renciation de cellules prog茅nitrices/souches neuronales (NSPC) dans le cerveau en d茅veloppement et postnatal, avec un int茅r锚t particulier pour le cortex c茅r茅bral.
- Caract茅riser les m茅canismes mol茅culaires sous-jacents 脿 la croissance et 脿 la propagation de la forme la plus maligne du cancer du cerveau, le glioblastome.
- Faire la lumi猫re sur les 茅v茅nements mol茅culaires contr么lant le d茅veloppement et l鈥檌nt茅gration des circuits neuronaux de divers sous-types de cellules nerveuses motrices (motoneurones), avec un int茅r锚t particulier pour les cellules vuln茅rables 脿 la d茅g茅n茅rescence dans les maladies des motoneurones comme la scl茅rose lat茅rale amyotrophique.
Murthy, M., Bocking, S., Verginelli, F., and听Stifani S. (2014) Transcription factor Runx1 inhibits proliferation and promotes developmental maturation in a selected population of inner olfactory nerve layer olfactory ensheathing cells.听Gene.听540(2):191-200. doi: 10.1016/j.gene.2014.02.038. Epub 2014 Feb 26.
Ciarapica, R., Carcarino, E., Adesso, L., De Salvo, M., Bracaglia, G., Leoncini, P.P., Dall鈥橝gnese, A., Verginelli, F., Milano, G.M., Boldrini, R., Inserra, A.,听Stifani, S., Screpanti, I, Marquez, V.E., Valente, S., Mai, A., Puri, P.L., Locatelli, F., Palacios, D., Rota R. (2014) Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS.听BMC Cancer.听14(1):139. doi: 10.1186/1471-2407-14-139.
Verginelli, F., Perin, A., Dali, R., Fung, K.H., Lo, R., Longatti, P., Guiot, M.C., Del Maestro, R.F., Rossi. S., di Porzio, U., Stechishin, O., Weiss, S.,听Stifani, S.听(2013) Transcription factors FOXG1 and Groucho/TLE promote glioblastoma growth.听Nature Commun. Dec 20;4:2956. doi: 10.1038/ncomms3956.
Perez-Campo, F.M., Costa, G., Lie-a-Ling, M.,听Stifani, S., Kouskoff, V., and Lacaud, G. (2014) MOZ-mediated repression of p16INK4a is critical for the self-renewal of neural and 听听听听听听听听听听 hematopoietic stem cells.听Stem Cells32:1591-1601. doi: 10.1002/stem.1606. Epub 2013 Dec 4.
Ciarapica, R., Methot, L., Tang, Y., Lo, R., Dali, R., Buscarlet, M., Locatelli, F., Del Sal, G., Rota, R., and听Stifani, S.(2014) Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation.听Cell Death Differ.听21(2):321-32. doi: 10.1038/cdd.2013.160. Epub 2013 Nov 22.
Ciarapica R., Bracaglia G., De Salvo M., Carcarino, E., Adesso, L., Leoncini P., Dall'Agnese 听听听听听听 A., Walters, Z., Verginelli F., De Sio L., Boldrini R., Inserra A, Bisogno G., Rosolen A., Alaggio R., Ferrari A., Collini P., Locatelli M.,听Stifani S.,听Screpanti I., Rutella S., Yu, Q., Marquez V., Shipley, J., Valente, S., Mai, A., Miele L., Puri P.L., Locatelli F., Palacios D., and Rota, S. (2014) Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing听FBXO32听(Atrogin1/MAFbx).听Oncogene. 33(32):4173-84. doi: 10.1038/onc.2013.471. Epub 2013 Nov 11.
Methot, L., Hermann, R., Tang, Y., Lo, R., Al-Jehani, H., Jhas, S., Svoboda, D., Slack, R.S., Barker, P.A., and听Stifani, S. (2013) Functional Interaction and Antagonistic Roles of NF-kappaB and Hes6 in the Regulation of Cortical Neurogenesis.听Mol Cell Biol.听33:2797-2808. doi: 10.1128/MCB.01610-12. Epub 2013 May 20.
Zusso, M., Methot, L., Lo, R., Grenhalgh, A.D., David, S., and听Stifani, S. (2012) Regulation of postnatal forebrain amoeboid microglial cell proliferation and development by the transcription factor Runx1.听J Neurosci.听32(33), 11285-11298.
Dastidar, S.G., Narayanan, S.,听Stifani, S., and D鈥橫ello, S. (2012) TLE1 combines with FoxG1 to promote neuronal survival.听J Biol Chem.听287(18):14749-14759.听Epub 2012 Feb 21.
Todd, K.J., Lan-Chow-Wing, N., Salin-Cantegrel, A., Cotter, A., Zagami, C.J., Lo R., and听Stifani, S. (2012) Establishment of motor neuron-V3 interneuron progenitor domain boundary in the ventral spinal cord requires Groucho-mediated transcriptional corepression.听PLoS One听7(2) e31176.听Epub 2012 Feb 17.
