Jesse Klostranec, MD, PhD
Dr. Klostranec is a diagnostic neuroradiologist and neurointerventional radiologist trained at the University of Toronto and the Universit茅 de Montr茅al. At the end of his fellowship he worked part time as a NIR at Health Sciences North in Sudbury Ontario where he helped kick-start their Stroke NIR program in 2020. He has been an assistant professor of diagnostic and interventional neuroradiology at the MUHC since November 2020.
His therapeutic NIR practice includes:
- mechanical thrombectomy for acute ischemic stroke
- embolization of intracranial aneurysms, arteriovenous malformations, dural arteriovenous fistulas, subdural hematomas, and tumours
- angioplasty and stenting of extracranial and intracranial atherosclerosis, and in select cases, venous stenting
- spinal angiography and related endovascular treatments
- a wide variety of minimally invasive spine procedures, including nerve root and facet blocks, synovial and Tarlov cyst treatments, vertebroplasty, kyphoplasty, and radiofrequency ablation of tumours
Dr. Klostranec has a PhD in Biomedical Engineering and BEng in Aerospace Engineering. Dr. Klostranec鈥檚 principle clinical and research interests revolve around diagnosing and treating diseases of the cerebrovascular system and conditions of altered cerebrospinal fluid dynamics in adult and pediatric patients. This includes developing clinical imaging techniques that assess the physiology of the glymphatic network, a special and unique 鈥渃irculation鈥� system for the interstitial and cerebrospinal fluid of the central nervous system. Such clinical tools have promising potential to aid in diagnosing, assessing progression, and therapeutic monitoring of numerous complex neurological pathologies, including dementias, hydrocephalus, traumatic brain injury, brain tumours, and stroke. Other research interests include understanding the clinical manifestations of dysfunctional angiogenesis and the development of diagnostic and therapeutic biomedical devices.
Specialist Medical Licenses:
Royal College of Physicians and Surgeons of Canada, Diagnostic Radiology - 2017
American Board of Radiology, Diagnostic Radiology - 2018
Royal College of Physicians and Surgeons of Canada, Neuroradiology - 2019
Klostranec, J. M., Krings, T. Cerebral Neurovascular Embryology, Anatomic Variations, and Congenital Brain Arteriovenous Lesions. Journal of NeuroInterventional Surgery (in press) (2022).
Klostranec, J. M., Vucevic, D., Bhatia, K. D., Kortman, H.G.J., Krings, T., Murphy, K.P., terBrugge, K.G., Mikulis, D.J. Current Concepts in Intracranial Interstitial Fluid Transport and the Glymphatic Model II: Imaging Techniques and Clinical Applications. Radiology 301(3) 516-32 (2021).
Klostranec, J. M., Vucevic, D., Bhatia, K. D., Kortman, H.G.J., Krings, T., Murphy, K.P., terBrugge, K.G., Mikulis, D.J. Current Concepts in Intracranial Interstitial Fluid Transport and the Glymphatic Model I: Anatomy and Physiology. Radiology 301(3) 502-14 (2021).
Klostranec, J. M., Rohringer, T., Gerber, R., Murphy, K.J. The Role of Biological Sex in Anaphylactoid Contrast Reactions: An Important Consideration for Women of Reproductive Age and on Hormone Replacement Therapy. Radiology 299 272-5 (2021).
Klostranec, J. M., Vucevic, D., Crawley, A.P., Venkatraghavan, L., Sobczyk, O., Duffin, J., Sam, K., Holmes, R., Mikulis, D.J., Fisher, J.A. Accelerated ethanol elimination via the lungs. Scientific Reports 10 19249 (2020).
Klostranec, J. M., Brinjikji, W., Mathur, S., Andrade, D. M., Krings, T. Cerebral Corticoarterial Malformations: A Case Series of Unilateral Polymicrogyria and Ipsilateral Arterial Dysplasias. Clinical Neuroradiology 30(2) 389-94 (2020).
Klostranec, J. M., Chen, L., Mathur, S., Faughnan, M. E., Ratjen, F., Krings, T. A Theory for Polymicrogyria and Brain Arteriovenous Malformations in HHT. Neurology 92(1) 34-42 (2019).
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