The labs of Dr John White and听Dr Jorg Fritz are seeking for an highly motivated postdoctoral fellow, who听can begin in May or June 2018. The postdoc should have expertise in flow cytometry and mouse work,听and听competence in Bioinformatics听would听be an asset. The听successful candidate听will work in both lab environments.听
Project Summary:The White laboratory identified LCoR (ligand-dependent corepressor) as a corepressor of ligand-bound nuclear receptors, a class of hormone-regulated transcription factors. Early work showed that LCoR repressed hormone-dependent transcription by recruiting CtBP corepressors and associated factors, as well as histone deacetylases (HDACs; Fernandes et al Molecular Cell, 2003). We have since characterized several novel interactions of LCoR with the transcriptional repressor KLF6 and the corepressor KAP-1 (Calderon et al J. Biol. Chem., 2012; Calderon et al, Nucleic Acids Research, 2014). Our current goals were to use a combination of bioinformatic, genomics and proteomics techniques to define the LCoR 鈥渋nteractome鈥�. French VersionLe laboratoire du Dr White a identifi茅 la prot茅ine LCor (ligand-dependent corepressor) comme co-r茅presseur de r茅cepteurs nucl茅aires, une cat茅gorie de facteurs de transcription r茅gul茅s par les hormones. Des travaux ant茅rieurs montraient que LCoR inhibe la transcription hormono-d茅pendantes en recrutant le co-r茅presseurs CtBP et ses facteurs associ茅s, ainsi que les histones d茅ac茅tylases听 (HDACs; Fernandes et al Molecular Cell, 2003). Depuis, nous avons caracteris茅 de nombreuses nouvelles int茅ractions de LCoR avec le r茅presseur transcriptionnel KLF6 et le co-r茅presseur KAP-1 (Calderon et al J. Biol. Chem., 2012;听Nucleic Acids Research, 2014). Notre objectif est actuellement de caract茅riser 芦听l鈥檌nteractome听禄 LCoR 脿 l鈥檃ide d鈥檕utils bio-informatiques, g茅nomiques et prot茅omiques. 听 |
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